“Free Book Reveals How To Naturally Reverse Your Fatty Liver, Reduce Fatigue, Relieve Joint Pain, And Finally Your Lose Stubborn Belly Fat”
Today’s Price: $0.00 (Regularly priced $34.95)
From: Jonathan Mizel
Author, Fix Your Fatty Liver
Dear Friend,
Amazon sells my book for as much as $47.00, but the next 100 customers can get it free of charge, just pay shipping and handling.
Keep reading this page for all the details to discover why we are doing this, and how you can benefit.
If You Suffer From Fatty Liver…
You will discover how I naturally dissolved my liver fat and safely flushed it from my system using a little-known diet.
That very same diet can also reduce fatigue, relieve muscle and joint pain, improve sleep, and help nearly anyone finally lose those extra pounds.
Over two BILLION people worldwide suffer from this, and the scary part is that most of them have no idea they have it!
A fatty liver takes years off your life. Even worse, it damages your quality of life by making you inflamed, overweight, and bloated, prematurely aging your skin, so you look and feel old.
In fact, it’s the number one health condition on the planet, and it’s getting worse every single day. But I promise, there’s a good chance you can do something about it, even if you were told otherwise.
That’s because around 80% of all fatty liver cases are reversible when you know what to do. Follow the right program, and you may be able to naturally heal your body and significantly reduce your symptoms, just like thousands of others have before you.
Do You Have Any Of These Symptoms?
Statistics say there’s a 1 in 3 chance you have fatty liver, even if you were never formally diagnosed. If you experience ANY of these risk factors, your liver is literally crying for help…
- You have extra weight on your belly, thighs, or hips
- You have high cholesterol
- You feel tired and sluggish
- You have mental fog and trouble focusing your attention
- Your vision is blurry or sensitive to light
- Your back or right side are constantly sore
- You have diarrhea or irregular bowel movements
- You were diagnosed with Syndrome X or heart disease
- You have dark or brown urine
- You have insulin resistance or diabetes
- You have trouble consuming alcohol
- Your eyes or skin seem to have a yellowish tinge
Don’t Ignore Your Liver!
If you ignore liver problems, you risk making your condition worse, and increase your chance of getting something even more serious down the road, like cirrhosis, diabetes, heart attack, stroke, even liver cancer.
I’m not trying to scare you, but this is serious, and you really want to take care of your liver, especially if you are overweight or have any physical pain. I didn’t figure out what was happening to me until after many months, and to be honest, it almost killed me.
Liver issues are NOT something you want to brush aside or “leave till later.” And believe me, they’re not going to fix themselves. You must take immediate action, because quite honestly, you may be living on borrowed time.
The Truth About Fatty Liver
Fatty liver is the fastest growing medical condition in the world right now, even bigger than diabetes, which is pretty staggering.
It affects nearly 1/3 of all men and women, and can be found wherever there is an abundance of junk-food, stress, a sedentary lifestyle, and people living in a toxic environment.
That’s scary, because the liver is considered by many to be one of the most important organs in your entire body.
It filters and eliminates toxins like alcohol, pollution, preservatives, and chemicals from your blood, acting like a giant filter, keeping the inner workings of your body clean and pure.
That you probably know. But you might not realize everything else your liver does, and how critical it is to your well being, health, even your looks…
- It metabolizes fats, carbohydrates, and proteins and keeps your weight stable.
- It regulates hormones that affect your happiness, energy, and emotional stability.
- It keeps your skin and eyes healthy, vibrant, and young.
- It stabilizes your blood sugar and cholesterol levels.
- It produces bile and bilirubin, aiding your digestion and elimination.
And That’s Just The Short-List!
Your liver performs over 400 different functions, which it normally does wonderfully… but there’s a kicker, and that’s when the fat content goes above 5% and it turns into fatty liver disease.
At that point, your body starts to go haywire and you may experience such a long list of seemingly unrelated ailments, it’s hard to imagine they’re all being caused by the same thing.
I’ll say that again because it’s very important…
When the fat content of your liver gets over 5% (and many people are up in the 10% – 15% range) it’s stops working correctly, and you end up with a ton of health issues you can no longer ignore…
Vision problems, headaches, brain fog, yellow skin and eyes, fatigue, inflammation, insomnia, belly fat, joint-pain, abdominal cramps, and brittle hair to name just a few.
All of them symptoms of an unhealthy liver that’s literally clogged-up with fat.
How Do People Get It?
There are multiple reasons so many people are getting fatty liver, but the biggest one by far has to do with our modern-day, over-processed, preservative-filled diet.
Food these days is convenient, there’s a fast food joint on every corner it seems. But the diet you and I were told was healthy is literally poisoning your body, overloading it with fat, sugar, alcohol, and simple, processed carbs (not to mention additives, pesticides, hormones, herbicides, antibiotics, GMOs, and chemical preservatives).
Now pay attention, because when the liver becomes poisoned, two VERY BAD things happen…
1. Your body starts storing fat: If you’ve been wondering why you are gaining weight all of a sudden, a likely culprit is a fatty liver, which throws your blood sugar out of whack, and puts you at risk for inflammation, insulin resistance, and diabetes.
2. Your blood becomes toxic: When toxic blood travels to your other organs (heart, lungs, skin, and especially your brain), it poisons your entire body. That explains the mental fog, skin issues, high cholesterol, joint-pain, clogged arteries, and frequent headaches you may be experiencing.
If any of those things are happening to you, consider it a wake up call to finally do something about it, and an opportunity to get healthy.
Is There A Cure?
You may have heard there’s no official cure for fatty liver. But I assure you, in many cases, there is a safe and reliable way to reverse it, and heal your body at the same time.
I should know, because I did it myself, 100% naturally, without the need for any drugs or expensive doctors visits or starving myself on the latest fad diet.
And that LONG list of symptoms? They just disappear once you restore your liver function…
- Liver fat naturally dissolves and is safely flushed out of your body, along with the chance that you’ll contract something serious like cirrhosis or liver cancer.
- Belly fat, love handles, and thighs shrink as your liver function and hormone levels return to their normal state and fat is expelled.
- Your skin gets softer and blemishes begin to clear up. You may find yourself looking years younger because there are no poisons irritating your skin. If you suffer from eczema, psoriasis, or dermatitis, it may go away on it’s own when your liver gets healthy.
- You will likely experience greater focus and concentration because your brain isn’t filled with toxic, acidic blood. You’ll be more alert and think clearer. Some people even believe a healthy liver makes you smarter.
- Vision improves and you see more clearly, especially in low light (easier to drive at night). Colors become more vibrant, and if you wear glasses, you may not need as strong a prescription.
- Many people sleep better, without drugs or constantly waking up. Start each morning well-rested and ready to make every day count.
- Because your liver helps with digestion, stomach and bowel problems are often reduced. Fats, sugars, and toxins are quickly eliminated via your healthy digestive system, while important nutrients and minerals are absorbed to help your body thrive.
- You might find yourself snapping out of depression and anger faster. Many people swear those feelings just melt away. Mood swings and stress may be significantly reduced as well.
And of course there are many improvements you can’t see, but you know are happening nonetheless:
- You add years to your life, perhaps even decades.
- You reduce your chance of a heart-attack, cirrhosis, stroke, or cancer.
- You decrease the likelihood of other major illnesses, like diabetes, arthritis, or digestive problems.
It’s really important for you figure this all out as soon as possible because…
Your Doctor Probably Won’t Be Much Help
Like I said before, the “official” story is that there’s no cure for fatty liver disease, which means you won’t get much help (or sympathy) from your doctor. In fact…
1. They might even blame you for your condition. When it comes to fatty liver, diabetes, heart problems, and weight issues, many doctors blame the patient, saying they have no self-control or they don’t exercise enough. The fact is though, most doctors refuse to admit how toxic our world has become, or how difficult it is to know which foods are actually healthy with all the conflicting information out there.
2. Misdiagnosis is common. The symptoms and physical ailments caused by fatty liver are so widespread and can appear so unrelated that your doctor may try to treat your symptoms just to move you through the system (and out of their office). This could actually make you much WORSE because any drug they prescribe is just one more toxin your already struggling liver has to deal with.
3. The information you receive is generic and useless. That’s what happened with me… My doctor kind of shrugged his shoulders after diagnosing me and handed me a photocopied pamphlet with generic info that wasn’t even specific to my condition. There was nothing about how I got it or how to get rid of it.
How I Naturally Reversed My Fatty Liver
My name is Jonathan Mizel. I’m a writer, Internet researcher, speaker, and health advocate. A few years ago, I was diagnosed with fatty liver, which to be honest shocked me.
I was never what you would consider fat, and I thought my diet was pretty good, especially when compared to my friends. It turns out though, I was very wrong.
Back in 2015, I woke up with a weird pain in my abdomen. At first, I thought maybe I pulled a muscle working out or gardening or something.
I tried to ignore it, but over the next month, it got more inflamed and the pain spread to my shoulder. At that point, everything just seemed to snowball…
I had trouble sleeping, which made me tired and fatigued during the day, so I started calling in sick because I couldn’t concentrate at work.
Then the weight gain started, and before I knew it, I was up a whopping 31 pounds. I felt slow and bloated all the time, like my food wasn’t digesting. None of my clothes fit anymore, which made me depressed.
Even worse, my skin broke out like a teenager, and I started getting rashes on my hand, which I found out later were a form of low-grade eczema.
I knew something was wrong, because I had honestly never felt so bad in my life. But when I went in to see my doctor, he was equally stumped.
I ended up going through a battery of blood-tests, X-rays, examinations, and a very expensive CT scan to finally get the the bottom of it, and what I discovered, literally changed my life.
The Main Types Of Fatty Liver Disease…
There are three main types of fatty liver disease…
- Non-Alcoholic Fatty Liver Disease (NAFLD) – Also known as “simple” fatty liver disease, NAFLD is the most common, and is probably what you have. It’s primarily caused by diet and exposure to environmental toxins like pollution and pesticides.
- Alcoholic Fatty Liver Disease (AFLD) – AFLD is mainly from drinking too much alcohol, which literally kills your liver and replaces healthy cells with fatty deposits.
- Non-Alcoholic Steatosis (NASH) – This is the most serious form of fatty liver, because it means some scarring has already occurred. It’s what I was diagnosed with. Left untreated, it can quickly turn into deadly cirrhosis and even liver-cancer, so my doctor wasn’t kidding when he said it could kill me.
Nearly 1/3 of the worlds population is affected by at least one of these, which means there’s a very good chance you have it, even if you were never formally diagnosed. The good news is that in about 80% of all cases, fatty liver is a completely reversible condition, provided you take care of it early.
Taking My Health Into My Own Hands…
I begged my doctor for help, but instead of giving me a treatment plan that would reverse the damage, or telling me how to start healing my liver, he literally told me there was nothing he could do.
He offered to put me on medication, but admitted there were side-effects. Plus it would only help my symptoms, and not the root cause of the problem.
I don’t know about you, but I’m too young to just give up hope. I have a family that depends on me, and the thought leaving them alone was simply too much.
Not to mention that my grandfather died of liver disease, and at the end, the only thing keeping him alive were feeding tubes and morphine, and frankly, that scared me more than anything else.
So I decided to take my health into my own hands and do something about it before it was too late and my liver was permanently damaged…
How I Lost 31 Pounds, Ended My Fatigue, And Relieved My Pain And Suffering
I devoted the last 5 years to figuring out exactly why people get fatty liver and how to treat it naturally, without any dangerous or expensive drugs.
I interviewed patients, doctors, and specialists. I studied liver function and nutrition. And since I really had nothing to lose, I used myself as a test subject and tried every diet, cleanse, supplement, and technique that seemed like it might actually work.
And the good news is…
In spite of what my doctor told me, I discovered a very specific diet and cleanse program that thousands of people were already using to successfully reverse their fatty liver.
It’s safe because it’s primarily food-based, and also extremely effective, because it deals with the root cause of the problem instead of just the symptoms.
Not to mention I also discovered…
- Why a traditional “Keto Diet” can kill you, and what to do instead to safely lose weight.
- A 7-cent enzyme supplement people with fatty liver should immediately add to their diet. You’ll digest your food up to 100% better, burn more carbs, and help your body absorb the wholesome nutrients.
- The nearly free amazing morning beverage that protects your liver, helps purify your blood, and cleanses your body. (Burns fat too, which is a plus.)
- How to safely detox and flush contaminants from your liver. This hits the reset button on your health and helps you feel and look better quickly.
- How big food companies create products that are more addictive than drugs, and then profit you when you get sick. (And how to protect yourself.)
- A “secret” supplement I take on cheat-days (or whenever I break my diet) that helps your liver dissolve processed food so your body can safely eliminate it. If you must cheat, this is a God-send.
- How to save hundreds, even thousands of dollars a year on all the medications and drugs you won’t have to buy anymore when you finally fix your liver.
- Is your sunscreen poisoning you? Many contain chemicals that can harm your liver and body. There are only two brands we recommend, and thankfully, they also protect you the best.
As for my doctor…
The next time I saw him, he was shocked since not all his patients recover from liver problems like I did. He said it looked like I would be one of the lucky ones, but I knew better…
Luck Had Nothing To Do With It!
It was about me figuring out how to reverse my condition when my doctor couldn’t help. It was discovering the truth about why people get fatty liver, and ultimately, how to get rid of it.
Depending on what’s wrong with you and how advanced your condition is, there’s a very good chance you can heal yourself like I did. You can almost certainly lessen your pain, and possibly have a complete recovery.
Many people start feeling better in just days after following the steps I took. That’s because the liver is one of the few organs able to regenerate itself, and naturally reverse damage from your past.
When you understand how to take care of it, you can get back to having a normal life again, without drugs or fatigue or any of the painful complications that fatty liver brings.
Fix Your Fatty Liver Program™
Over the past 5 years, I’ve met hundreds of people who have reversed their condition, and have heard from thousands more who have used my program to achieve success.
When I started this journey, I was surprised there was nothing available to help people who have this condition, especially since it’s so widespread. So I took everything I discovered and put it together in an easy-to-follow book called Fix Your Fatty Liver™.
If you have any symptoms and want to experience relief, try this for yourself, because I believe it’s the best information on the market. And through the special page, I want to give it to you free of charge.
Here’s What You Will Discover…
- How to specifically deal with all three types of fatty liver: Non-Alcoholic Fatty Liver Disease (NAFLD). Alcoholic Fatty Liver Disease (AFLD), and Non-Alcoholic Steatohepatisis (NASH).
- The best fatty liver diet, and why what you eat is way more important than exercise when it comes to fixing your body and losing weight.
- 17 environmental (home and work) toxins that are probably poisoning your liver on a daily basis without your knowledge!
- If anyone tells you people with fatty liver need to avoid eating fat, they don’t know what they’re talking about. You actually want to eat a very ‘specific’ type of fat, and I recommend you do it every single day.
- A list of foods you NEVER want to eat because they poison your body, make you acidic, encourage inflammation, and cause you to store fat in your liver (and your belly). Some of these are even so-called HEALTH foods!
- My amazing 7-Day Liver-Detox Plan™ that includes exactly what to eat to clean out your liver, purify your blood and body, and jump-start your weight-loss.
- Three powerful herbs you can get at the supermarket, that are inexpensive and incredibly effective when it comes to healing a compromised liver. These have been used for thousands of years, and unlike pharmaceuticals, they have very few side-effects.
- The incredible green-drink that tastes great and flushes fat from your system, helping to regenerate healthy tissue. I drink one every day.
- There are hundreds of different vitamins, minerals, and supplements for liver function, but only 14 are proven by science to actually work. Get the short list.
- Many people know probiotics are important, but there’s only one kind we recommend for people with liver issues.
- How to replace chemicals, cleaners, and poisons from around your house with natural alternatives that actually work better, and won’t harm your liver.
You’ll learn all that and more from the Fix Your Fatty Liver™ book. When you get it, you will finally understand how to…
Fix The Root Cause Of Your Problem For Good
Please don’t spend your hard-earned money on pain medication, sleeping pills, energy drinks, or anything else to feel better.
You aren’t fixing the root cause of the problem, you are simply dealing with the symptoms. Your liver will keep getting worse, and you will need to take greater and greater doses just to get relief.
I should know. I spent thousands of dollars to COVER up my problems since I didn’t understand why they were happening in the first place.
It was only when I discovered the truth, how it occurs and how to naturally eliminate it, that I was able to get lasting relief, and finally feel like my old self again.
If I Can Do This, Anyone Can
Listen, I don’t have super willpower or extra strength or anything special like that (ask my wife). All I had was a genuine desire to feel better and get back to my old life again.
If you sincerely want that too, this program was created specifically for you. It will help you improve your health across the board. You’ll look better and feel better and possibly add years to your lifespan.
In fact, there’s zero downside to getting this taken care of, especially if you have any of the symptoms listed above. That’s what my book shows you how to do. But don’t take it from me…
Real Customer Feedback
Below are some comments from real customers who experienced significant results from using our program…
“An amazing program that really works!”
This is an amazing program that really works! My last blood work showed improvement and my doctor advised me to continue what I’m doing to completely heal my liver.
“Lost 28 lbs, the pain is going away, off all my meds”
Not any good at writing a testimonial but I can tell you that I’ve lost 28 lbs, the pain is going away, off all my meds and I feel better than I’ve felt in a long time. Plus I have more energy than ever before. Thank you so much!
“My doctors didn’t tell me this!”
When I thought I had no way to feel better and all hope was lost I found something that really works! I Love how easy it is to get back to a healthy way of living; energy, no aches and pains any more. Appreciate this information so much, doctors didn’t tell me this!
“My hot flashes have gone away”
Been doing 1 month and down 9 lbs and feel so much better! My hot flashes have gone away and I sleep all night, something I haven’t done in years. So, Thank You!
Results not typical, your experience may vary.
Why Are We Giving It Away Free?
I personally spent thousands on tests, treatments, cleanses, classes, books, nutrition coaches, and supplements, trying to figure everything out.
To be honest, I would have spent much more if I had to. You really can’t put a price on health and happiness and well-being and increased life expectancy.
Right now, you can get everything I discovered on my quest to reverse and heal my own fatty liver, for a one-time payment of $47.00 $0.00 (just pay shipping and handling).
We decided to test giving this program away for free to people who need it because so many are looking for help, and they aren’t getting it from the traditional medical establishment.
You could spend years researching all this on your own, and figuring out for yourself what really works. Instead, benefit of my years of experience, and the same treatment plan that helped me get my health (and life) back.
And if you are one of the first 100 people to say yes, you get it for free, just pay shipping and handling.
Fix Your Fatty Liver™ Today!
Please Don’t Wait Too Long!
Fixing your fatty liver is NOT impossible, heck, it’s not even that hard if you have a system to follow. Unlike what you may have been told, there is a natural treatment program that really works, and that thousands of people are using to feel better and reverse their condition.
But you must take care of this now. If you have any symptoms at all, you do NOT want to wait until your fatty liver turns into cirrhosis or liver cancer. The longer you put this off, the harder it’s going to be to recover, and at a certain point, you could even need a liver transplant.
Please don’t wait that long!
If you value your health, your family, and your life, pick up Fix Your Fatty Liver™ now.
Join Today And Get Everything Free…
Discover how I reversed and healed my own fatty liver, and how you can too, 100% naturally, without drugs, crazy exercises, or starving yourself. Works for all types of fatty liver, including NAFLD, AFLD, and NASH.
You’ll love our favorite liver-friendly recipes (including shopping lists and meal plans), sorted by what we recommend for breakfast, lunch, dinner, and snacks. If you aren’t sure what you can eat, start with this.
Our amazing 7-day liver cleanse and detox program, including daily schedule, juice and smoothie recipes, and relaxation exercises to help you overcome insomnia, stress, and emotional issues relating to your liver.
Safe And Secure Ordering
This site uses the latest technology to keep your information safe. Our order forms employ 128 bit Secure Socket Layer (SSL) encryption, and our site is regularly scanned for spyware, viruses, and security holes.
After you securely place your order, you will receive a confirmation by email, and another when your package is shipped. Your order will be sent by UPS ground within 72 hours, and should arrive within 10 – 14 days. (Canadian orders please allow extra time to clear customs.)
Are You Ready To Finally
Free Yourself From Pain And Suffering?
At this point, you need to ask yourself if you are ready to start living the way you were meant to, free from fatigue and pain and all the other symptoms of a fatty liver.
You have three options…
1. You can do nothing and keep “ignoring” your problem. You’ll find yourself getting sicker, heavier, and angrier. You increase your risk of stroke, heart attack, cirrhosis, and liver cancer. Do you really want that for yourself?
2. You can keep treating your symptoms, instead of solving the root cause of the issue. Keep spending thousands of dollars on pain relievers, sleeping pills, and other medications, even though you know it’s not helping you get better, it’s only covering up the problem.
OR….
3. You can get Fix Your Fatty Liver™ now, and finally do something about it. Take care of the issue once and for all, reclaim your life, and start living on your own terms again.
If you are anything like our other customers, you will finally drop those extra pounds, end your pain, get a good night’s sleep, and experience the comfort that people with a healthy liver feel.
First 100 Customers Get Fix Your Fatty Liver™ Free!
You owe it to yourself to try this.
Sincerely,
Jonathan Mizel
PS: This is what I used to reverse and heal my own fatty liver. It’s designed to improve your health even if you haven’t been officially diagnosed yet. There’s literally no downside to getting your liver healthy again. Many people experience more energy, less fatigue, and finally lose those extra pounds they’ve been carrying around for years.
PPS: Looking for our recommended fatty liver supplement? Click here.
“All numbers are fantastic according to my doctor!”
Nine months after my diagnosis and my liver enzymes are back to normal, triglycerides down, cholesterol is great.
So I thank you profusely!!! I told my doctor about your program and friends and family how beneficial it was for me. I’m so glad I found it before things got worse! God Bless you & I wish you continued good health!
“My tummy is coming down”
I have dropped from 158 to 149 lbs, and my tummy is coming down. Thanks for your concern, care and love.
“Tests show my liver is healthy again!”
I’m doing much better, I had tests done last week and my liver is healthy again!
Thank you so much!
“I really liked the way it’s organized.”
Loved the schedule, that was awesome as i love structure, and that has helped a lot, along with giving the list of good foods. Highly recommend to anyone who cares about their liver health.
Results not typical, your experience may vary.
Fix Your Fatty Liver™ Today!
Scientific References:
Nonalcoholic fatty liver disease:
https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/symptoms-causes/syc-20354567
Aging and Liver Disease:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736713
Economic burden of fatty liver disease in US is $32 billion annually, new study finds:
https://www.sciencedaily.com/releases/2018/07/180703105956.htm
Patient Care & Health Information
https://www.mayoclinic.org/diseases-conditions/liver-problems/symptoms-causes/syc-20374502
Fatty liver disease is the ticking time bomb you’ve never heard of:
https://www.scmp.com/lifestyle/health-wellness/article/2147128/fatty-liver-disease-ticking-time-bomb-youve-never-heard
Fatty liver disease and your heart:
https://www.health.harvard.edu/heart-health/fatty-liver-disease-and-your-heart
Non-Alcoholic Fatty Liver Disease:
https://www.uofmhealth.org/conditions-treatments/digestive-and-liver-health/fatty-liver-disease-non-alcoholic
Human Anatomy:
https://www.webmd.com/digestive-disorders/picture-of-the-liver#1
What does the liver do?
https://www.medicalnewstoday.com/articles/305075.php
Fatty Liver: What It Is, and How to Get Rid of It:
https://www.healthline.com/nutrition/fatty-liver
7 subtle signs that your liver is not healthy :
https://www.health24.com/Medical/Liver-Health/Liver-disease/7-subtle-signs-that-your-liver-is-not-healthy-20180613
Diabetes: How do I help protect my liver?
https://www.mayoclinic.org/diseases-conditions/diabetes/expert-answers/diabetes/faq-20058461
Main Types Of Fatty Liver Disease:
https://medlineplus.gov/fattyliverdisease.html
Information on Detoxification:
issels.com/publication-library/information-on-detoxification
Toxic Sunscreens:
https://articles.mercola.com/sites/articles/archive/2014/06/04/ewg-sunscreen-guide.aspx
The skinny on fatty liver disease:
https://www.health.harvard.edu/diseases-and-conditions/the-skinny-on-fatty-liver-disease
Can liver damage be reversed?
https://uihc.org/health-topics/liver-disease-frequently-asked-questions
Fatty Liver Disease: Diet and Supplements:
https://www.webmd.com/hepatitis/fatty-liver-disease-diet#1
Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237220/
Long term prognosis of fatty liver: risk of chronic liver disease and death:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774026/